Search on: ANTIGENS, CD86 
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Descriptor English:   Antigens, CD86 
Descriptor Spanish:   Antígenos CD86 
Descriptor Portuguese:   Antígenos CD86 
Synonyms English:   B7-2 Costimulatory Molecule
CD86 Antigens  
Tree Number:   D12.776.467.150.200
D12.776.543.095.200
D23.050.301.264.035.276.200
D23.050.301.285.200
D23.101.100.110.276.200
D23.529.168.200
Definition English:   A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. 
History Note English:   2006(1993) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   51076 
Unique Identifier:   D051940 

Occurrence in VHL: 		 

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