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APHIDICOLIN
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DeCS
Descriptor
English
:
Aphidicolin
Descriptor
Spanish
:
Afidicolina
Descriptor
Portuguese
:
Afidicolina
Tree Number:
D02.455.849.291.075
Definition
English
:
An antiviral antibiotic produced by Cephalosporium aphidicola and other
fungi
. It inhibits the
growth
of
eukaryotic cells
and certain animal
viruses
by selectively inhibiting the cellular replication of
DNA polymerase II
or the viral-induced
DNA
polymerases. The drug may be useful for controlling excessive
cell proliferation
in
patients
with cancer,
psoriasis
or other
dermatitis
with little or no adverse effect upon non-multiplying
cells.
Pharmacological Action:
Antiviral Agents
Enzyme Inhibitors
History Note
English
:
92; was APHIDICOLIN (NM) 1974-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30254
Unique Identifier:
D016590
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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