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ARABINOFURANOSYLCYTOSINE
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DeCS
Descriptor
English
:
Cytarabine
Descriptor
Spanish
:
Citarabina
Descriptor
Portuguese
:
Citarabina
Synonyms
English
:
Ara-C
Arabinofuranosylcytosine
Arabinosylcytosine
Cytosine Arabinoside
Tree Number:
D03.383.742.680.245.453
D13.570.065.300
D13.570.685.245.453
Definition
English
:
A pyrimidine nucleoside analog that is used mainly in the treatment of
leukemia
, especially acute non-lymphoblastic
leukemia
.
Cytarabine
is an antimetabolite antineoplastic agent that inhibits the synthesis of
DNA
. Its actions are specific for the
S phase
of the
cell cycle
. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Pharmacological Action:
Antimetabolites, Antineoplastic
Antiviral Agents
Immunosuppressive Agents
History Note
English
:
66
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
3578
Unique Identifier:
D003561
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS