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DeCS
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Descriptor English:
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Anti-Inflammatory Agents, Non-Steroidal
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Descriptor Spanish:
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Antiinflamatorios no Esteroideos
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Descriptor Portuguese:
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Antiinflamatórios não Esteróides
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Synonyms English:
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Aspirin-Like Agents
Non-Steroidal Anti-Inflammatory Agents
Analgesics, Anti-Inflammatory
Anti-Rheumatic Agents, Non-Steroidal
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Tree Number:
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D27.505.696.663.850.014.040.500
D27.505.954.158.030
D27.505.954.329.030
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Definition English:
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Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5) |
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Indexing Annotation English:
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GEN or unspecified: prefer specifics; DF: NSAID
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See Related English:
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Cyclooxygenase Inhibitors
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History Note English:
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87; ANALGESICS, ANTI-INFLAMMATORY was heading 1975-89
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Allowable Qualifiers English:
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Record Number:
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27938
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Unique Identifier:
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D000894
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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