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CD40 ANTIGENS
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DeCS
Descriptor
English
:
Antigens, CD40
Descriptor
Spanish
:
Antígenos CD40
Descriptor
Portuguese
:
Antígenos CD40
Synonyms
English
:
CD40 Antigens
Tumor Necrosis Factor Receptor Superfamily, Member 5
Tree Number:
D12.776.543.750.705.852.760.097
D23.050.301.264.035.140
D23.050.301.264.051.140
D23.101.100.110.140
D23.101.100.150.140
Definition
English
:
A member of the tumor
necrosis
factor receptor superfamily with specificity for
CD40 LIGAND
. It is found on mature
B-LYMPHOCYTES
and some
EPITHELIAL CELLS
, lymphoid
DENDRITIC CELLS
. Evidence suggests that CD40-dependent activation of B-cells is important for generation of
memory
B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in
HYPER-IGM IMMUNODEFICIENCY SYNDROME
, TYPE 3. Signaling of the receptor occurs through its
association
with TNF RECEPTOR-ASSOCIATED FACTORS.
See Related
English
:
CD40 Ligand
History Note
English
:
96; was CD40 ANTIGEN (NM) 1989-95 & CDW40 ANTIGEN (NM) 1988-95
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32846
Unique Identifier:
D019013
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS