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CIP-KIP CYCLIN-DEPENDENT KINASE INHIBITORS
Descriptors Found:
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DeCS
Descriptor
English
:
Cyclin-Dependent Kinase Inhibitor Proteins
Descriptor
Spanish
:
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
Descriptor
Portuguese
:
Proteínas Inibidoras de Quinase Dependente de Ciclina
Synonyms
English
:
CIP-KIP Cyclin-Dependent Kinase Inhibitors
INK4 Cyclin-Dependent Kinase Inhibitors
Tree Number:
D12.644.360.225
D12.776.167.187
D12.776.476.225
D12.776.624.776.355
Definition
English
:
A group of
cell cycle proteins
that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit
CELL CYCLE
progression and help
control
CELL PROLIFERATION
following GENOTOXIC STRESS as well as during
CELL DIFFERENTIATION.
Pharmacological Action:
Protein Kinase Inhibitors
History Note
English
:
2006
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50927
Unique Identifier:
D050756
Occurrence in VHL
:
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CID-10
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