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CYP3A
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP3A
Descriptor
Spanish
:
Citocromo P-450 CYP3A
Descriptor
Portuguese
:
Citocromo P-450 CYP3A
Synonyms
English
:
CYP3A
Tree Number:
D08.244.453.040.986
D08.811.682.662.582.353
D08.811.682.690.708.170.040.888
D12.776.422.220.453.040.972
Definition
English
:
A cytochrome P-450 monooxygenase that is involved in an NADPH-dependent
electron transport
pathway by oxidizing a variety of structurally unrelated compounds, including
STEROIDS
;
FATTY ACIDS
; and
XENOBIOTICS
. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as
CYCLOSPORINE
;
VERAPAMIL
; and
MIDAZOLAM
. This enzyme also catalyzes the N-demethylation of
ERYTHROMYCIN.
History Note
English
:
2006(1980)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50572
Unique Identifier:
D051544
Occurrence in VHL
:
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DeCS
CID-10
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