Search on: CALCIUM-ACTIVATED NEUTRAL PROTEASE 
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Descriptor English:   Calpain 
Descriptor Spanish:   Calpaína 
Descriptor Portuguese:   Calpaína 
Synonyms English:   Calcium-Activated Neutral Protease
Calcium-Dependent Neutral Proteinase  
Tree Number:   D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
Definition English:   Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4. 
Indexing Annotation English:   /biosyn /physiol permitted
History Note English:   86 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   23227 
Unique Identifier:   D002154 

Occurrence in VHL: 		 

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