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CYTOCHROME P-450 CYP1A2
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP1A2
Descriptor
Spanish
:
Citocromo P-450 CYP1A2
Descriptor
Portuguese
:
Citocromo P-450 CYP1A2
Synonyms
English
:
CYP1A2
Phenacetin O-Dealkylase
Tree Number:
D08.244.453.040.777
D08.811.682.690.708.170.040.443
D12.776.422.220.453.040.555
Definition
English
:
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic
xenobiotics
in the
liver
of human and several animal species. This enzyme is of significant clinical interest due to the large number of
drug interactions
associated with its induction and its
metabolism
of
THEOPHYLLINE
.
Caffeine
is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette
smoking
, charbroiled
meat
, cruciferous
vegetables
, and a number of drugs including
phenytoin
,
phenobarbital
, and
omeprazole.
Indexing Annotation
English
:
do not confuse with other cytochrome P-450 CYP's
History Note
English
:
97; was PHENACETIN O-DEALKYLASE (NM) 1976-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33009
Unique Identifier:
D019388
Occurrence in VHL
:
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