Search on: CYTOCHROME P-450 CYP2D6 
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Descriptor English:   Cytochrome P-450 CYP2D6 
Descriptor Spanish:   Citocromo P-450 CYP2D6 
Descriptor Portuguese:   Citocromo P-450 CYP2D6 
Synonyms English:   CYP2D6
Debrisoquine Hydroxylase
Debrisoquine 4-Hydroxylase  
Tree Number:   D08.244.453.040.944
D08.811.682.690.708.170.040.555
D12.776.422.220.453.040.888
Definition English:   A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population. 
Indexing Annotation English:   do not confuse with other cytochrome P-450 CYP's
History Note English:   97; was DEBRISOQUINE 4-HYDROXYLASE (NM) 1982-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33011 
Unique Identifier:   D019389 

Occurrence in VHL:
 

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