Search on: FACTOR VIII, THROMBIN-ACTIVATED 
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Descriptor English:   Factor VIIIa 
Descriptor Spanish:   Factor VIIIa 
Descriptor Portuguese:   Fator VIIIa 
Synonyms English:   Factor VIII, Activated
Factor VIII, Thrombin-Activated
Coagulation Factor VIIIa  
Tree Number:   D12.776.124.125.350.300
D23.119.350.300
Definition English:   Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va. 
Entry Combination - descr/qualif English:   Factor VIIIa/deficiency use Hemophilia A
 
See Related English:   Coagulants
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   24644 
Unique Identifier:   D015944 

Occurrence in VHL: 		 

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