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FOCAL ADHESION KINASE 1
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DeCS
Descriptor
English
:
Focal Adhesion Kinase 1
Descriptor
Spanish
:
Quinasa 1 de Adhesión Focal
Descriptor
Portuguese
:
Quinase 1 de Adesão Focal
Tree Number:
D08.811.913.696.620.682.725.049.500
D12.776.744.493
Definition
English
:
A non-receptor protein
tyrosine
kinase that is localized to
FOCAL ADHESIONS
and is a central component of integrin-mediated
SIGNAL TRANSDUCTION
PATHWAYS.
Focal adhesion kinase 1
interacts with
PAXILLIN
and undergoes
PHOSPHORYLATION
in response to adhesion of cell surface
integrins
to the
EXTRACELLULAR MATRIX
. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing
proteins
and helps regulate
CELL ADHESION
and CELL
MIGRATION.
History Note
English
:
2006(1986)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50729
Unique Identifier:
D051417
Occurrence in VHL
:
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