Search on:
FUROCOUMARINS
Descriptors Found:
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DeCS
Descriptor
English
:
Psoralens
Descriptor
Spanish
:
Psoralenos
Descriptor
Portuguese
:
Psoralenos
Synonyms
English
:
Furocoumarins
Furanocoumarins
Tree Number:
D03.438.150.446.794
D03.494.770
D03.830.219.446.794
Definition
English
:
Linear furanocoumarins which are found in many
PLANTS
, especially UMBELLIFERAE and
RUTACEAE
, as well as
PSORALEA
from which they were originally discovered. They can intercalate
DNA
and, in an UV-initiated reaction of the furan portion, alkylate
PYRIMIDINES
, resulting in
PHOTOSENSITIVITY DISORDERS.
Indexing Annotation
English
:
dermatol agents; do not confuse with the specific drug PSORALEN see
FICUSIN
; do not index here for
psoralens
in
PUVA THERAPY
unless particularly discussed
Pharmacological Action:
Dermatologic Agents
Photosensitizing Agents
See Related
English
:
Coumarins
History Note
English
:
79
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
12001
Unique Identifier:
D011564
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS