Search on: G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS 
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Descriptor English:   G Protein-Coupled Inwardly-Rectifying Potassium Channels 
Descriptor Spanish:   Canales de Potasio Rectificados Internamente Asociados a la Proteína G 
Descriptor Portuguese:   Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G 
Tree Number:   D12.776.157.530.400.600.450.500
D12.776.543.550.425.750.450.500
D12.776.543.585.400.750.450.500
Definition English:   A family of inwardly-rectifying potassium channels that are activated by PERTUSSIS TOXIN sensitive G-PROTEIN-COUPLED RECEPTORS. GIRK potassium channels are primarily activated by the complex of GTP-BINDING PROTEIN BETA SUBUNITS and GTP-BINDING PROTEIN GAMMA SUBUNITS. 
History Note English:   2006(1993) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50867 
Unique Identifier:   D051676 

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