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INTERFERON REGULATORY FACTOR-3
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DeCS
Descriptor
English
:
Interferon Regulatory Factor-3
Descriptor
Spanish
:
Factor 3 Regulador del Interferón
Descriptor
Portuguese
:
Fator Regulador 3 de Interferon
Synonyms
English
:
IRF-3 Transcription Factor
Tree Number:
D12.644.360.024.302.374
D12.776.157.057.050.374
D12.776.260.504.374
D12.776.476.024.385.374
D12.776.744.562
D12.776.930.332.374
Definition
English
:
An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral
infection
.
PHOSPHORYLATION
of IRF-3 causes the protein to be translocated from the
CYTOPLASM
to
CELL NUCLEUS
where it binds
DNA
, and activates transcription.
History Note
English
:
2006(1996)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50777
Unique Identifier:
D050838
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS