Search on: L-TYPE VDCC ALPHA-1 SUBUNIT 
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Descriptor English:   Calcium Channels, L-Type 
Descriptor Spanish:   Canales de Calcio Tipo L 
Descriptor Portuguese:   Canais de Cálcio Tipo L 
Synonyms English:   Dihydropyridine Receptors
L-Type Calcium Channels
L-Type VDCC alpha-1 Subunit
Long-Lasting Calcium Channels
Receptors, Dihydropyridine  
Tree Number:   D12.776.157.530.400.150.400
D12.776.543.550.425.150.400
D12.776.543.585.400.150.400
Definition English:   Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites. 
Indexing Annotation English:   DF: VDCC L
History Note English:   2000; use L-TYPE CALCIUM CHANNELS (NM) 1993-1999 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   34475 
Unique Identifier:   D020746 

Occurrence in VHL:
 

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