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MDR1 PROTEIN
Descriptors Found:
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DeCS
Descriptor
English
:
P-Glycoprotein
Descriptor
Spanish
:
P-Glicoproteína
Descriptor
Portuguese
:
Glicoproteína P
Synonyms
English
:
MDR1 Protein
Multidrug Resistance Protein 1
Tree Number:
D12.776.157.530.100.652.500
D12.776.157.530.450.074.500.500.750
D12.776.395.550.020.610.610
D12.776.543.550.192.610.610
D12.776.543.585.100.610.500
D12.776.543.585.450.074.500.500.750
Definition
English
:
A 170-kDa transmembrane glycoprotein from the superfamily of
ATP-BINDING CASSETTE TRANSPORTERS
. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many
ANTINEOPLASTIC AGENTS
. Overexpression of this glycoprotein is associated with multidrug resistance (see
DRUG RESISTANCE
, MULTIPLE).
Indexing Annotation
English
:
P-GLYCOPROTEINS
is also available
Entry Combination - descr/qualif
English
:
P-Glycoprotein
/
analogs & derivatives
use
P-Glycoproteins
See Related
English
:
Drug Resistance, Multiple
History Note
English
:
99; use P-GLYCOPROTEIN 1995-98
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32100
Unique Identifier:
D020168
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS