Search on: PKC-ALPHA SERINE-THREONINE KINASE 
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Descriptor English:   Protein Kinase C-alpha 
Descriptor Spanish:   Proteína Quinasa C-alfa 
Descriptor Portuguese:   Proteína Quinase C-alfa 
Synonyms English:   PKC-alpha Serine-Threonine Kinase  
Tree Number:   D08.811.913.696.620.682.700.725.100
Definition English:   A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells. 
History Note English:   2006(1999) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50721 
Unique Identifier:   D051571 

Occurrence in VHL: 		 

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