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PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE
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DeCS
Descriptor
English
:
Phosphatidylcholine-Sterol O-Acyltransferase
Descriptor
Spanish
:
Fosfatidilcolina-Esterol O-Aciltransferasa
Descriptor
Portuguese
:
Fosfatidilcolina-Esterol O-Aciltransferase
Synonyms
English
:
Lecithin Cholesterol Acyltransferase
Lecithin Acyltransferase
Tree Number:
D08.811.913.050.625
Definition
English
:
An enzyme secreted from the
liver
into the
plasma
of many mammalian species. It catalyzes the
esterification
of the hydroxyl group of lipoprotein
cholesterol
by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:
cholesterol
acyltransferase deficiency
disease
, the absence of the enzyme results in an excess of unesterified
cholesterol
in
plasma
. EC 2.3.1.43.
Entry Combination - descr/qualif
English
:
Phosphatidylcholine-Sterol O-Acyltransferase
/
deficiency
use
Lecithin Acyltransferase Deficiency
History Note
English
:
98(75)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
8040
Unique Identifier:
D007862
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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