Search on: SQUALENE MONOOXYGENASE 
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Descriptor English:   Squalene Monooxygenase 
Descriptor Spanish:   Escualeno-Monooxigenasa 
Descriptor Portuguese:   Esqualeno Monooxigenase 
Tree Number:   D08.811.682.690.708.749
Definition English:   The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide. 
History Note English:   2006(1980); use ETHERS, CYCLIC 1970-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50664 
Unique Identifier:   D050603 

Occurrence in VHL: 		 

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