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UBIQUITIN-PROTEIN LIGASE COMPLEXES
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DeCS
Descriptor
English
:
Ubiquitin-Protein Ligase Complexes
Descriptor
Spanish
:
Complejos de Ubiquitina-Proteína Ligasa
Descriptor
Portuguese
:
Complexos Ubiquitina-Proteína Ligase
Tree Number:
D08.811.464.938
Definition
English
:
Complexes of
enzymes
that catalyze the covalent attachment of
UBIQUITIN
to other
proteins
by forming a peptide bond between the C-terminal
GLYCINE
of
UBIQUITIN
and the alpha-amino groups of
LYSINE
residues in the protein. The complexes play an important
role
in mediating the selective-degradation of short-lived and abnormal
proteins
. The complex of
enzymes
can be broken down into three components that involve activation of
ubiquitin
(
UBIQUITIN-ACTIVATING ENZYMES
), conjugation of
ubiquitin
to the ligase complex (
UBIQUITIN-CONJUGATING ENZYMES
), and
ligation
of
ubiquitin
to the substrate protein (
UBIQUITIN-PROTEIN LIGASES
).
Indexing Annotation
English
:
UBIQUITIN-PROTEIN LIGASES
is also available
History Note
English
:
2004
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38180
Unique Identifier:
D043743
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS