Search on: C-BCL-2 PROTEINS 
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Descriptor English:   Proto-Oncogene Proteins c-bcl-2 
Descriptor Spanish:   Proteínas Proto-Oncogénicas c-bcl-2 
Descriptor Portuguese:   Proteínas Proto-Oncogênicas c-bcl-2 
Synonyms English:   bcl-2 Proto-Oncogene Proteins
c-bcl-2 Proteins  
Tree Number:   D12.644.360.075.718
D12.776.476.075.718
D12.776.624.664.700.169
Definition English:   Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. 
History Note English:   97; was PROTO-ONCOGENE PROTEIN BCL-2 (NM) 1989-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33061 
Unique Identifier:   D019253 

Occurrence in VHL:
 

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