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DeCS
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Descriptor English:
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eIF-2 Kinase
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Descriptor Spanish:
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eIF-2 Quinasa
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Descriptor Portuguese:
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eIF-2 Quinase
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Synonyms English:
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p68 Kinase
Protein Kinase PKR
Protein Kinase, RNA Activated
RNA-Dependent Protein Kinase
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Tree Number:
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D08.811.913.696.620.682.700.300
D12.644.360.275
D12.776.476.275
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Definition English:
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A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. |
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History Note English:
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98; use EIF-2 KINASE (NM) 1980-97
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Allowable Qualifiers English:
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Record Number:
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33472
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Unique Identifier:
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D019892
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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