Search on: PARC PROTEIN 
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Descriptor English:   DNA Topoisomerase IV 
Descriptor Spanish:   Topoisomerasa de ADN IV 
Descriptor Portuguese:   DNA Topoisomerase IV 
Synonyms English:   parC Protein
parE Protein  
Tree Number:   D08.811.399.403.741.224
D12.776.097.256
Definition English:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication. 
History Note English:   2002; use DNA TOPOISOMERASE IV (NM) 1991-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36090 
Unique Identifier:   D027101 

Occurrence in VHL:
 

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