Search on:
ACTIVIN RECEPTOR-LIKE KINASES
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Activin Receptors
Descriptor
Spanish
:
Receptores de Activinas
Descriptor
Portuguese
:
Receptores de Ativinas
Synonyms
English
:
Activin Receptor-Like Kinases
Tree Number:
D08.811.913.696.620.682.700.062
D12.776.543.750.750.400.820.500
Definition
English
:
Receptors for
ACTIVINS
are membrane
protein kinases
belonging to the
family
of
PROTEIN-SERINE-THREONINE KINASES
, thus also named activin receptor-like kinases (ALK's).
Activin receptors
also bind
TRANSFORMING GROWTH FACTOR BETA
. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS,
TRANSFORMING GROWTH FACTOR BETA
), ALK's consist of two different but related
protein kinases
, Type I and Type II.
Activins
initiate cellular
signal transduction
by first binding to the type II receptors (
ACTIVIN RECEPTORS
, TYPE II ) which then recruit and phosphorylate the type I receptors (
ACTIVIN RECEPTORS
, TYPE I ) with subsequent activation of the type I kinase activity.
History Note
English
:
2002; use ACTIVIN RECEPTORS (NM) 1991-2001
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
36116
Unique Identifier:
D029404
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS