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AFLATOXIN M1
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DeCS
Descriptor
English
:
Aflatoxin M1
Descriptor
Spanish
:
Aflatoxina M1
Descriptor
Portuguese
:
Aflatoxina M1
Tree Number:
D03.438.150.119.100
D03.830.219.119.100
D23.946.587.142.100
Definition
English
:
A 4-hydroxylated metabolite of
AFLATOXIN B1
, one of the
MYCOTOXINS
from
ASPERGILLUS
tainted
food
. It is associated with
LIVER
damage and cancer resulting from its P450 activation to the epoxide which alkylates
DNA
.
Toxicity
depends on the balance of
liver
enzymes
that activate it (CYTOCHROME P-450) and others that detoxify it (
GLUTATHIONE
S TRANSFERASE) (Pharmac Ther 50.443 1991).
Primates
& rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
Indexing Annotation
English
:
/antag permitted but consider also
ANTITOXINS
; DF: AFM1
Pharmacological Action:
Poisons
History Note
English
:
92; was AFLATOXIN (NM) 1980-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30276
Unique Identifier:
D016607
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS