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ANESTHETICS, LOCAL
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DeCS
Descriptor
English
:
Anesthetics, Local
Descriptor
Spanish
:
Anestésicos Locales
Descriptor
Portuguese
:
Anestésicos Locais
Synonyms
English
:
Anesthetics, Conduction-Blocking
Conduction-Blocking Anesthetics
Tree Number:
D27.505.696.277.100.200
D27.505.696.663.850.025
D27.505.954.427.210.100.200
Definition
English
:
Drugs that block nerve
conduction
when applied locally to
nerve tissue
in appropriate concentrations. They act on any part of the
nervous system
and on every type of nerve fiber. In contact with a nerve trunk, these
anesthetics
can cause both sensory and motor
paralysis
in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of
Therapeutics
, 8th ed) Nearly all local
anesthetics
act by reducing the tendency of voltage-dependent
sodium channels
to activate.
Indexing Annotation
English
:
see note at
ANESTHETICS
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
790
Unique Identifier:
D000779
Occurrence in VHL
:
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DeCS
CID-10
SciELO
LILACS
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