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CLOSTRIDIUM BOTULINUM TOXINS
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DeCS
Descriptor
English
:
Botulinum Toxins
Descriptor
Spanish
:
Toxinas Botulínicas
Descriptor
Portuguese
:
Toxinas Botulínicas
Synonyms
English
:
Botulin
Clostridium botulinum Toxins
Tree Number:
D08.811.277.656.300.480.153
D08.811.277.656.675.374.153
D12.776.097.156
D23.946.123.179
Definition
English
:
Toxic
proteins
produced from the species
CLOSTRIDIUM BOTULINUM
. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and
light
chain joined via a disulfide bond. The
botulinum
toxin
light
chain is a zinc-dependent protease which is released from the heavy chain upon
ENDOCYTOSIS
into PRESYNAPTIC
NERVE ENDINGS
. Once inside the cell the
botulinum
toxin
light
chain cleaves specific
SNARE proteins
which are essential for secretion of
ACETYLCHOLINE
by
SYNAPTIC VESICLES
. This inhibition of
acetylcholine
release results in muscular
PARALYSIS.
Indexing Annotation
English
:
/antag permitted but consider also
BOTULINUM ANTITOXIN
Pharmacological Action:
Anti-Dyskinesia Agents
Poisons
See Related
English
:
Botulism
History Note
English
:
78; was BOTULINUM TOXIN 1969-77 (Prov 1969-71)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
1930
Unique Identifier:
D001905
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS