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COCAINE
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DeCS
Descriptor
English
:
Cocaine
Descriptor
Spanish
:
Cocaína
Descriptor
Portuguese
:
Cocaína
Tree Number:
D02.145.074.722.388
D03.132.889.354
D03.605.869.388
D04.075.080.875.099.722.388
Definition
English
:
An alkaloid ester extracted from the leaves of
plants
including
coca
. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the
eye
,
ear
,
nose
, and throat. It also has powerful
central nervous system
effects
similar
to the
amphetamines
and is a drug of abuse.
Cocaine
, like
amphetamines
, acts by multiple mechanisms on
brain
catecholaminergic
neurons
; the mechanism of its reinforcing effects is thought to involve inhibition of
dopamine
uptake.
Indexing Annotation
English
:
cocaine
derivatives =
COCAINE
/analogs;
CRACK COCAINE
is available;
cocaine
addiction =
COCAINE-RELATED DISORDERS
Pharmacological Action:
Anesthetics, Local
Dopamine Uptake Inhibitors
Vasoconstrictor Agents
History Note
English
:
COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
3070
Unique Identifier:
D003042
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS