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FACTOR VIII, THROMBIN-ACTIVATED
Descriptors Found:
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DeCS
Descriptor
English
:
Factor VIIIa
Descriptor
Spanish
:
Factor VIIIa
Descriptor
Portuguese
:
Fator VIIIa
Synonyms
English
:
Factor VIII, Activated
Factor VIII, Thrombin-Activated
Coagulation Factor VIIIa
Tree Number:
D12.776.124.125.350.300
D23.119.350.300
Definition
English
:
Activated form of
factor VIII
. The B-domain of
factor VIII
is proteolytically cleaved by
thrombin
to form
factor VIIIa
.
Factor VIIIa
exists as a non-covalent dimer in a metal-linked (probably
calcium
) complex and functions as a cofactor in the enzymatic activation of
factor X
by
factor IXa
.
Factor VIIIa
is
similar
in structure and generation to
factor Va.
Entry Combination - descr/qualif
English
:
Factor VIIIa
/
deficiency
use
Hemophilia A
See Related
English
:
Coagulants
History Note
English
:
90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
24644
Unique Identifier:
D015944
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS