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G-PROTEIN, INHIBITORY GI
Descriptors Found:
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DeCS
Descriptor
English
:
GTP-Binding Protein alpha Subunits, Gi-Go
Descriptor
Spanish
:
Subunidades alfa de la Proteína de Unión al GTP Gi-Go
Descriptor
Portuguese
:
Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP
Synonyms
English
:
Gi, Inhibitory G-Protein
G-Protein, Inhibitory Gi
G-Protein, Gi-Go alpha Family
Tree Number:
D08.811.277.040.330.300.200.100.200
D12.644.360.375.100.200
D12.776.157.325.332.100.200
D12.776.476.375.100.200
D12.776.543.325.100.200
Definition
English
:
A
family
of heterotrimeric
GTP-binding protein alpha subunits
that were originally identified by their ability to inhibit
ADENYLATE CYCLASE
. Members of this
family
can couple to beta and gamma G-protein subunits that activate
POTASSIUM CHANNELS
. The Gi-Go part of the name is also spelled Gi/Go.
Indexing Annotation
English
:
DF: G PROTEIN INHIB GI
History Note
English
:
2004(1997); for GUANINE NUCLEOTIDE-BINDING PROTEIN GO use GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO (NM) 1997-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33044
Unique Identifier:
D019206
Occurrence in VHL
:
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CID-10
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