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GABA MODULATORS
Descriptors Found:
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DeCS
Descriptor
English
:
GABA Modulators
Descriptor
Spanish
:
Moduladores GABA
Descriptor
Portuguese
:
Moduladores GABAérgicos
Synonyms
English
:
gamma-Aminobutyric Acid Modulators
Tree Number:
D27.505.519.625.240.500
D27.505.696.577.240.500
Definition
English
:
Substances that do not act as agonists or antagonists but do
affect
the
GAMMA-AMINOBUTYRIC ACID
receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which
BENZODIAZEPINES
act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated
chloride channels
; a site at which
BARBITURATES
act to prolong the duration of channel opening; and a site at which some
steroids
may act. GENERAL
ANESTHETICS
probably act at least partly by potentiating GABAergic responses, but they are not included here.
Indexing Annotation
English
:
GEN or unspecified; prefer specifics
See Related
English
:
Anesthetics, General
Anti-Anxiety Agents
Hypnotics and Sedatives
History Note
English
:
95
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
32238
Unique Identifier:
D018757
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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