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GLOBOSIDES
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DeCS
Descriptor
English
:
Globosides
Descriptor
Spanish
:
Globósidos
Descriptor
Portuguese
:
Globosídeos
Synonyms
English
:
Cytolipins
Lacto-N-neotetraosylceramide
Lacto-N-tetraosylceramide
Tree Number:
D02.065.313.425
D09.400.410.420.525.200.425
D10.390.470.675.200.425
D10.570.877.360.612.200.425
Definition
English
:
Glycosphingolipids
containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on
erythrocytes
and paragloboside is an intermediate in the biosynthesis of erythrocyte
blood
group ABH and P 1 glycosphingolipid
antigens
. The accumulation of globoside in tissue, due to a defect in
hexosaminidases
A and B, is the cause of
Sandhoff disease.
Indexing Annotation
English
:
/biosyn /physiol permitted
History Note
English
:
91(79); was see under GLYCOSPHINGOLIPIDS 1979-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
6060
Unique Identifier:
D005915
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS