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HISTAMINE-PRODUCING CELL-STIMULATING FACTOR
Descriptors Found:
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DeCS
Descriptor
English
:
Granulocyte-Macrophage Colony-Stimulating Factor
Descriptor
Spanish
:
Factor Estimulante de Colonias de Granulocitos y Macrófagos
Descriptor
Portuguese
:
Fator Estimulador de Colônias de Granulócitos e Macrófagos
Synonyms
English
:
CSF-GM
GM-CSF
Colony-Stimulating Factor, Granulocyte-Macrophage
Histamine-Producing Cell-Stimulating Factor
Tree Number:
D12.644.276.374.410.240.375
D12.776.395.240.300
D12.776.467.374.410.240.375
D23.529.374.410.240.375
Definition
English
:
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal
cells
present in the hemopoietic
environment
and at peripheral sites of
inflammation
. GM-CSF is able to stimulate the production of neutrophilic
granulocytes
,
macrophages
, and mixed granulocyte-macrophage colonies from
bone marrow cells
and can stimulate the formation of eosinophil colonies from fetal
liver
progenitor
cells
. GM-CSF can also stimulate some functional activities in mature
granulocytes
and
macrophages.
Indexing Annotation
English
:
DF: GMCSF
See Related
English
:
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
History Note
English
:
91; HISTAMINE-PRODUCING CELL-STIMULATING FACTOR was HISTAMINE-PRODUCING CELL STIMULATING FACTOR see INTERLEUKIN-3 1987-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28969
Unique Identifier:
D016178
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS