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MITOGEN-ACTIVATED PROTEIN KINASE 2
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DeCS
Descriptor
English
:
Mitogen-Activated Protein Kinase 1
Descriptor
Spanish
:
Proteína Quinasa 1 Activada por Mitógenos
Descriptor
Portuguese
:
Proteína Quinase 1 Ativada por Mitógeno
Synonyms
English
:
p42 MAPK
p42(Mitogen-Activated Protein Kinase)
Extracellular Signal-Regulated Kinase 2
p42 MAP Kinase
MAP Kinase 2
Mitogen-Activated Protein Kinase 2
Tree Number:
D08.811.913.696.620.682.700.567.342.500
D08.811.913.696.620.682.700.646.750.249.500
D12.644.360.450.169.500
D12.776.476.450.169.500
Definition
English
:
A proline-directed serine/threonine protein kinase which mediates
signal transduction
from the cell surface to the nucleus. Activation of the enzyme by
phosphorylation
leads to its translocation into the nucleus where it acts upon specific
transcription factors
. p40 MAPK and p41 MAPK are isoforms.
Indexing Annotation
English
:
Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases
History Note
English
:
2005(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33471
Unique Identifier:
D019950
Occurrence in VHL
:
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DeCS
CID-10
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