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RESERPINE
Descriptors Found:
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DeCS
Descriptor
English
:
Reserpine
Descriptor
Spanish
:
Reserpina
Descriptor
Portuguese
:
Reserpina
Tree Number:
D03.132.436.681.933.500
D03.438.473.402.681.933.500
Definition
English
:
An alkaloid found in the roots of
Rauwolfia serpentina
and R. vomitoria.
Reserpine
inhibits the uptake of
norepinephrine
into storage vesicles resulting in depletion of
catecholamines
and
serotonin
from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a
research
tool, but its adverse effects limit its clinical use.
Indexing Annotation
English
:
reserpine
derivatives=RESERPINE /analogs
Pharmacological Action:
Adrenergic Uptake Inhibitors
Antihypertensive Agents
Antipsychotic Agents
History Note
English
:
RESERPINE DERIVATIVES was see under RESERPINE 1975-77, was see under YOHIMBANS 1969-74; /adv eff-pois-tox was RESERPINE TOXICOLOGY 1963-65
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
12531
Unique Identifier:
D012110
Occurrence in VHL
:
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DeCS
CID-10
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