1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
Heavy Chain Disease
|
Descriptor Spanish:
|
|
Enfermedad de las Cadenas Pesadas
|
Descriptor Portuguese:
|
|
Doença das Cadeias Pesadas
|
Synonyms English:
|
|
Franklin Disease
gamma-Chain Disease
mu-Chain Disease
|
Tree Number:
|
|
C15.378.147.780.490
C15.604.515.435
C20.683.780.490
|
Definition English:
|
|
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes. |
Indexing Annotation English:
|
|
specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available
|
See Related English:
|
|
Immunoglobulin Heavy Chains
|
History Note English:
|
|
66(64)
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
6512
|
Unique Identifier:
|
|
D006362
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS CID-10 SciELO LILACS LIS
|