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OLIGOMYCINS
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DeCS
Descriptor
English
:
Oligomycins
Descriptor
Spanish
:
Oligomicinas
Descriptor
Portuguese
:
Oligomicinas
Tree Number:
D02.540.505.620
Definition
English
:
A closely related group of
toxic substances
elaborated by various strains of
Streptomyces
. They are 26-membered
macrolides
with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of
phosphorylation
from mitochondrial
respiration
. Used as tools in cytochemistry. Some specific
oligomycins
are
RUTAMYCIN
, peliomycin, and botrycidin (formerly venturicidin X).
Pharmacological Action:
Anti-Bacterial Agents
Enzyme Inhibitors
Uncoupling Agents
History Note
English
:
82; was OLIGOMYCIN 1963-81 (Prov 1963-65)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
10026
Unique Identifier:
D009840
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS