Search on: BETA-MANNOSIDASE 
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Descriptor English:   beta-Mannosidase 
Descriptor Spanish:   beta-Manosidasa 
Descriptor Portuguese:   beta-Manosidase 
Synonyms English:   beta-D-Mannosidase  
Tree Number:   D08.811.277.450.625.750
Definition English:   An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS. 
Indexing Annotation English:   /defic: consider also BETA-MANNOSIDOSIS
See Related English:   beta-Mannosidosis
 
History Note English:   2004; use BETA-MANNOSIDASE (NM) 1980-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38164 
Unique Identifier:   D044902 

Occurrence in VHL:
 

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