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PARAPROTEINS
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DeCS
Descriptor
English
:
Paraproteins
Descriptor
Spanish
:
Paraproteínas
Descriptor
Portuguese
:
Paraproteínas
Tree Number:
D12.776.124.486.485.900
D12.776.124.790.651.900
D12.776.377.715.548.900
Definition
English
:
Abnormal
immunoglobulins
synthesized by atypical
cells
of the
MONONUCLEAR PHAGOCYTE SYSTEM
.
Paraproteins
containing only
light
chains
lead
to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to
heavy chain disease
. Most of the
paraproteins
show themselves as an M-component (monoclonal gammopathy) in
electrophoresis
. Diclonal and polyclonal
paraproteins
are much less frequently encountered.
Pharmacological Action:
Immunologic Factors
History Note
English
:
76; was see under GLOBULINS 1963-65
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22253
Unique Identifier:
D010266
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS